Small molecule kinase interaction maps for FLT3 inhibitors. Compounds were screened against a KinomeScan (http://www.kinomescan.com) panel of 402 kinase assays. Red circles indicate kinases bound, and circle size indicates binding affinity. Interactions with K_d < 3 μM are shown. The complete dataset is shown in supplemental Table 1, and is also available through an interactive website (http://www.ambitbio.com/technology/publications). The data for MLN-518, PKC-412, sunitinib, and sorafenib against a subset of 317 of the 402 assays were previously published,⁴⁴  and are reproduced here together with new data for assays not represented in the earlier panel. The kinase dendrogram was adapted and is reproduced with permission from Cell Signaling Technology Inc (http://www.cellsignal.com).