In vitro cell binding and transduction of HVR5 and 7 mutant adenoviruses. (A) Cell binding at 4°C to SKOV3 cells in the presence or absence of physiologic concentrations of FX. (B) Fold change in FX-assisted virus association with cell versus absence of FX. (C) SKOV3 cell transduction at 48 hours postinfection after a 3-hour exposure to each virus in the presence or absence of FX in serum-free conditions (P < .01 vs no FX conditions).