Schematic representation of the JAK2 3′UTR region and miR-135a binding. (A) miR-135a is predicted by TargetScan to target JAK2 mRNA in the position 935 to 942 of its 3′UTR region. (B) On the left, the predicted hybridization of miR-135a and JAK2 mRNA by the Pictar database. The minimum free energy required (mfe) for RNA hybridization is shown. On the right, the predicted hybridization of miR-135a and JAK2 mRNA by miRbase (seed sequence, 8mer).