miR-34a expression in CD19⁺ B cells of TCL1 transgenic mice and B-CLL patients both normalized to the corresponding healthy controls. (A) miR-34a expression levels during the course of disease in TCL1 transgenic mice (mean value ± SD; *P < .05; **P < .01). (B) miR-34a expression in B-CLL patients is higher compared with healthy controls. Box length equals interquartile range.