TLR4 (LPS) and TLR7/8 (resiquimod) pretreatment reduces bacteremia during polymicrobial sepsis. Bacteremia (log of colony forming units/mL) in sham (normal saline, □) and TLR agonist–(resiquimod-, ; LPS-, ▨; poly I:C–, ) pretreated neonates (n = 7) at 6 and 12 hours after sepsis. Medians, are indicated by ▬ and quartiles (25th and 75th percentiles) by the surrounding rectangles. Statistical significance (*P < .05 by 1-way ANOVA) was present for resiquimod versus sham (normal saline), resiquimod versus poly I:C, LPS versus sham, and LPS versus poly I:C at 6 hours after sepsis as well as LPS versus resiquimod, sham, and poly I:C at 12 hours after sepsis.