TLR pretreatment increases and abbreviates the early neonatal inflammatory response following sepsis. Plasma cytokine levels and chemokine levels (pg/mL) at 4 and 24 hours after TLR agonist treatment (time points −20 and 0 hours, respectively) and at 12 and 24 hours after sepsis. LPS (●), resiquimod (◇), poly I:C (□), and sham (normal saline; ▵). The time point “zero” refers to the time sepsis was initiated. Values plotted represent medians, with error bars representing quartiles (75%/25%). Values that reached statistical significance (P < .05 by 1-way ANOVA) were too numerous to represent and are reported in “Results.”