TLR7/8 (resiquimod) and TLR4 (LPS) agonist–enhanced survival in neonatal mice with polymicrobial sepsis is independent of the adaptive immune system and type I IFN signaling. Kaplan-Meier survival curves for RAG-1–deficient (A) and IFNAR-null (B) neonates following sham (♦; normal saline) or TLR agonist pretreatment (resiquimod 5 μg/gm BW; ■) or LPS (1 μg/gm BW; ▵) versus wild-type sham (normal saline; ◇) and subsequent administration of cecal slurry (1.3 mg/g LD₇₀).