Dose response to TSA in the NY1DD mouse. VCAM (A) and TF (B) in the NY1DD mouse illustrate dose-response to TSA pretreatment. In both panels, the 2 leftmost open bars illustrate the already described (in Figure 1) status in NY1DD animals at air and after H/R. Black bars show effect of TSA pretreatment of NY1DD animals then exposed to H/R. (A) *P < .001; **P = .04; ***P = .002. (B) #P = .009; *P < .001; **P = .003. Number of animals for bars left to right: top panel, 4, 4, 6, 3, 3, and 3; bottom panel, 4, 4, 6, 3, 3, and 3.These data illustrate that a pretreatment TSA dose of 1 mg/kg is the minimal efficacious dose. Error bars show ±SD.