Protein and gene structure for Mndal. (A) Two BAC clones harbor Mndal sequences. BAC clones are oriented to show gene order on Chr 1 from centromere to telomere. The ORF of Mndal starts at exon 2 and finishes in exon 9. Sequence analysis of genomic DNA showed a segment absent in DBA from within intron 1 of Ifi203 to intron 2 of Mndal. *Exon 5 harbors sequences unique to Mndal. (B) Predicted structural domains of MNDAL. The canonical HIN “a” domain is highlighted in black and contains the highly conserved MFHATVAT motif thought to mediate dimerization and protein-protein interactions. The protein also contains a nuclear localization signal (NLS), a possible Rb-binding site (LxCxD), and several weak (S/T-P) Cdk2 sites.