Candidate Scl target genes. (A) Diagram of identified Scl target genes and relative location within cellular compartments; cytoskeleton, mitochondrion, nucleus, cytoplasm, endoplasmic reticulum, Golgi, plasma membrane, and extracellular region/secreted proteins. (B) Representative grouping of gene ontology of candidate Scl target genes. Candidate target genes were classified into functionally related categories using the DAVID analysis tool.^32,33  Significance of group classification was defined by enrichment scores based on Fisher exact statistics. Overrepresented categories are greater than 1, whereas underrepresented categories are smaller than 1.