Increased monocyte turnover in SIV/SHIV-infected rhesus macaques. (A) Histograms of BrdU-labeled blood monocytes in uninfected and SIV/SHIV-infected animals and in animals with AIDS at 24 hours after BrdU treatment. Representative data from 2 animals per group are shown. Percentage values in histograms indicate BrdU⁺ CD14⁺ monocytes. (B) The percentage of BrdU-labeled monocytes in uninfected (n = 17) and chronically SIV- or SHIV-infected monkeys (n = 24) and in monkeys with AIDS (n = 5). P values were calculated by the Mann-Whitney U test. More information on the infected monkeys used in this study is provided in Table 1. Horizontal bars indicate the average percentage of BrdU⁺ CD14⁺ monocytes in each group. (C) Blood monocyte counts in monkeys before (n = 17; total 155 time points) and after infection (n = 17; total 156 time points) and in other monkeys with AIDS (n = 5; total 5 time points). Each bar indicates the average of monocyte counts in an individual monkey. P values were calculated by the Wilcoxon matched pairs test for the comparison between before and after infection and by the Mann-Whitney U test for the comparison between before infection and AIDS group. Error bars indicate SD of monocyte counts.