Endotoxemic WT and Sdc1^−/− mice show similar systemic inflammatory and hemostatic responses. Mice were injected with LPS, and (A) serum levels of TNFα, IL-1β, IL-6, IL-10, KC, and MIP-2 were determined by ELISA at the indicated times after LPS (n = 5), (B) circulating platelets were measured by CBC analysis before and 48 hours after LPS (n = 3; Bayer Advia 120 hematology analyzer), and (C) plasma TAT levels were determined by ELISA at the indicated times after LPS (n = 4). Error bars indicate SE.