Overview of biologic networks of differently expressed genes. Relation between different genes is based on Ingenuity knowledge database and was generated using Ingenuity Pathways Analysis (Ingenuity Systems). (A) SAM analysis of the AML-M0 samples versus the primary AML samples showed down-regulation of several transcription factors depicted here in an integrated network. Genes up- and down-regulated in AML-M0 are represented in red and green, respectively. (B) SAM analysis of AML-M0s groups A and B showed up-regulation of many B cell–related genes in group B (associated with RUNX1 mutation), several of which are here represented together with other genes. Red represents up-regulation in group B; green, down-regulation; and white, no difference in expression.