Display of mean IC₅₀ values for MDM2-inhibitor-induced CLL apoptosis/necrosis. IC₅₀ values for the MDM2 inhibitors MI-63 (A) and nutlin3 (B): MDM2 inhibitor-mediated CLL cell apoptosis was measured in purified CD19⁺ cells as described.²  SNP309 genotyping was done using genomic polymerase chain reaction across MDM2 SNP309. Displayed are mean IC₅₀ values grouped by MDM2 SNP309 genotype (TT, TG, GG) and 95% confidence bars.