The tilt angle between repeats is large in βI-14,15. Comparison with previously determined spectrin di-repeat structures reveals that the tilt angle between repeats βI-14 and βI-15 is the largest observed so far in any spectrin, and is similar to that observed in some plakin repeats. Depicted is least-squares superpositioning of βI-14,15 (red) with: (A) Repeats 16 and 17 of the chicken α-spectrin (blue, PDBID: 1CUN); (B) Repeats 15 and 16 of chicken α-spectrin (green; PDBID: 1U5P); (C) Erythroid spectrin repeats 8 and 9 (gold; PDBID: 1S35); (D) The BPAG1 di-repeat structure (light blue; PDBID: 2IAK). The βI-14 repeat was used as a reference molecule for superpositioning.