Figure 1
Agonist-induced platelet activation in subjects P1 and P2. (A-C) Platelet aggregation in response to the indicated concentrations of arachidonic acid (AA), U46619, PAR 1 agonist, and CRP in citrated PRP from subject P1 and healthy control platelets collected on the same day. Platelet aggregation to 3μM of U46619 was also tested in the presence of indomethacin (10μM). (D) Aggregation responses to U46619 are also shown in PRP from subject P2 who had the same variant D304N TxA2R as P1. The results are representative of 2 experiments.
