Inhibition of ALL cell proliferation by AKT inhibitor. ALL cell lines from both T-cell (A) and B-cell (B) origin were treated with varying concentration of GSK690693 for 72 hours. Cell proliferation was measured as described in “Methods.” Graphs represent curve fit analysis of the dose response data for a subset of cell lines analyzed. Please note the relative insensitivity of MN60 and Tanoue cells to GSK690693. (C) Effect of GSK690693 on the proliferation of primary human CD4⁺ T lymphocytes, mouse thymocytes, and an AKT inhibitor-sensitive T-ALL cell line, A3.