Figure 4
ceacam1−/− platelets show hyper-responsive aggregation in response to stimulation with GPVI-selective agonists. Aggregation responses of PRP (platelet count adjusted to 100 × 109/L) for wild-type and ceacam1−/− mice were determined after activation with different concentrations of various agonists: PAR-4 agonist peptide (100-250 μM), ADP (5-20 μM), calcium ionophore (0.3-2.5 μg/mL), collagen-related peptide (0.62-2.5 μg/mL) and collagen (1.5-4 μg/mL) respectively. Note that ceacam1−/− platelets are hyper-responsive in collagen and CRP-induced platelet aggregation. These results are representative of at least 3 independent experiments.
