Improvements in hematological, visceral, and skeletal parameters: overall and stratified by baseline disease severity. (A-F) Data are reported as means ± SD. N = 20, except n = 16 for lumbar spine BMD (excluding 4 patients for receipt of zoledronate during the study [n = 1], assessment with different DEXA machines at different time points [n = 1], lack of 1-year data [n = 1], or presence of radiographic abnormalities preventing BMD assessment [n = 1]). BMD indicates bone mineral density; MN, multiples of normal (volume); F, female; and M, male. Baseline lumbar spine BMD T-scores were categorized as normal, osteopenic, or osteoporotic, as previously described.¹¹