Figure 4
![Figure 4. Graphs depicting the effect of DMPS on biodistributions in tumors, kidneys, blood, lungs, livers, and spleens of athymic mice bearing Ramos xenografts injected with 1F5 or CC49 FPs followed by a CA and [213Bi]DOTA-biotin. (A) The activity of 213Bi following 1F5(scFv)4SA in the tissues of mice not treated with DMPS (B) The effect of the chelating agent DMPS on the normal organ and tumor uptake of 213Bi when administered in the drinking water. The radioactivity in tumor, blood, and normal organs were quantified by gamma counting, corrected for decay and expressed as the % ID/g of tissue. The % ID/g is shown as function of time after injection.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/116/20/10.1182_blood-2010-05-282327/7/zh89991060470004.jpeg?Expires=1735846874&Signature=tvXluWVf2NRSUdpcWGiSDxQaOgBu~rqMqWZpt8kkojUVlx6z58V-wfuMFuiIOayOU1DhAN-XGhPY7Bserp1YpkJnC5K7pvPgNqb1mc8nuhm8UncDTH2ipmHkfBT4mJEOhVPd309TgFRfiY7uVWHJ4ojJDU2McyeuNgPkdCUkqtE~-uoX7op1mPAmxyRnUWU9pLtmRZJkiDk1xyAVoILss8GzValPf9~3Bit4WE1BaKgmBBuHu~8hg8MbEoG4ZRvnAKWX~yjDv7ik-fMlg40y3NuyeDgYbEJN12pwEqPGf0V-CTqwRnOmMJ7o2jDDBH~Z-ndvq~xaNOkeueA0AOt0Lg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Graphs depicting the effect of DMPS on biodistributions in tumors, kidneys, blood, lungs, livers, and spleens of athymic mice bearing Ramos xenografts injected with 1F5 or CC49 FPs followed by a CA and [213Bi]DOTA-biotin. (A) The activity of 213Bi following 1F5(scFv)4SA in the tissues of mice not treated with DMPS (B) The effect of the chelating agent DMPS on the normal organ and tumor uptake of 213Bi when administered in the drinking water. The radioactivity in tumor, blood, and normal organs were quantified by gamma counting, corrected for decay and expressed as the % ID/g of tissue. The % ID/g is shown as function of time after injection.
