Analysis of tumor size, cumulative survival, and toxicity of mice bearing large-sized Ramos lymphoma xenografts treated with 1F5 or CC49 FPs followed by a CA and [²¹³Bi]DOTA-biotin. (A) Responses of large tumors (6-10 mm in diameter) to PRIT. The sizes of Ramos tumor xenografts were serially measured in athymic mice treated with either 1F5 or CC49 FP followed by NAGB CA and 200, 600, or 800 μCi (7.4, 14.8, or 29.6 MBq, respectively) [²¹³Bi]DOTA-biotin. An additional control group bearing xenograft tumors received no treatment. Animals were killed when tumors reached > 10% of the body weight. To minimize fluctuations in the graph and facilitate interpretation of the data, the mean tumor volume for each group was plotted until > 50% of the mice in the group were killed. (B) Kaplan-Meier survival curves of mice bearing Ramos lymphoma xenografts (∼ 6-10 mm in diameter) treated with either 1F5 or CC49 FPs followed by NAGB CA and 200, 600, or 800 μCi (7.4, 14.8, or 29.6 MBq, respectively) of [²¹³Bi]DOTA-biotin. Survival curves in this figure correspond to treatment groups designated in panel A. (C) Weight as assessment of general health in mice bearing Ramos lymphoma xenografts treated as described in panels A and B. Weight curves in this figure correspond to treatment groups designated in panels A and B.