Figure 3
Figure 3. Turbidimetric clot lysis curves. Fibrin clot polymerization/lysis curves for each patient (solid line) were generated in parallel with 2 different healthy controls (dotted lines) by measuring absorbance at 405 nm at 1-minute intervals for 1 hour at room temperature. Each panel represents a separate experiment and each experiment was repeated 2 to 3 times. A representative experiment for each fibrinogen variant is shown. (A) FibrinogenSan Diego I, Bβ P235L/γ R375W; (B) fibrinogenSan Diego II, Bβ P235L/γ Y114H; (C) fibrinogenSan Diego III, Bβ P235L; (D) fibrinogenSan Diego IV, Aα L69H; (E) fibrinogenSan Diego V, Aα R554H.

Turbidimetric clot lysis curves. Fibrin clot polymerization/lysis curves for each patient (solid line) were generated in parallel with 2 different healthy controls (dotted lines) by measuring absorbance at 405 nm at 1-minute intervals for 1 hour at room temperature. Each panel represents a separate experiment and each experiment was repeated 2 to 3 times. A representative experiment for each fibrinogen variant is shown. (A) FibrinogenSan Diego I, Bβ P235L/γ R375W; (B) fibrinogenSan Diego II, Bβ P235L/γ Y114H; (C) fibrinogenSan Diego III, Bβ P235L; (D) fibrinogenSan Diego IV, Aα L69H; (E) fibrinogenSan Diego V, Aα R554H.

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