Mouse pulmonary embolism model. C57Bl/6 mice were given a single 100-μL bolus of rabbit brain tissue factor (∼ 1nM solution), and time to cessation of respiration was measured. The mice tested are wild-type (WT: ●), fXI-deficient (fXI^−/−: ■), fXII-deficient (fXII^−/−: ▴) and WT treated with 1.0 mg/kg 14E11 (▾). Each symbol represents one animal, and bars within the column of symbols indicate the mean occlusion time. The box plots indicate the 25th, 50th, and 75th percentile for each group, with the whiskers showing the 10th and 90th percentile.