Baboon AV shunt thrombosis model. (A) Shown are aPTT clotting times (see “Methods”) of plasma from a male baboon treated with a single subcutaneous injection of 14E11 (1 mg/kg) at time zero. (B and C) Platelet deposition over time for 4 separate collagen coated grafts, 2 inserted into the shunt before treatment with 14E11 (○, □) and 2 inserted 24 hours after a 1-mg/kg subcutaneous dose of 14E11 (●, ■). Deposition of ¹¹¹I-labeled platelets was measured with a gamma scintillation camera, as described in “Methods.” Panel B shows accumulation of platelets within the graft, while panel C shows the bulk of platelet accumulation in a thrombus forming in the 10 cm immediately downstream of the graft.