EphrinB2-Fc and EphB4-Fc affect neovascularization in myelomatous bone. Human bone sections from myelomatous SCID-hu mice treated with Fc, ephrinB2-Fc, or EphB4-Fc were immunohistochemically stained for human CD34. (A) Numbers of human CD34-reactive neomicrovessels in myelomatous bones were increased by ephrinB2-Fc and reduced by EphB4-Fc treatment. (B) Representative immunohistochemical staining for CD34, demonstrating the effect of ephrinB2-Fc and EphB4-Fc on MM-induced neovascularization.