More CD56^dimCD16⁺CD57⁺ NK cells express KIR and LIR-1 than CD56^dimCD16⁺CD57⁻ NK cells. CD56^dimCD16⁺ NK cells that are CD57⁺ or CD57⁻ were assessed for the expression of LIR-1 and KIRs. (A) Representative histogram of LIR-1 expression (shaded area represents isotype-matched control Ig; thin line, CD57⁺; and bold line, CD57⁻). The percentage of cells expressing LIR-1 was determined in each subset. (B) The percentage of cells expressing each KIR was determined in each subset. ● represents CD57⁺; and ◇, CD57⁻. *P < .05. ***P < .0005. (A-B) P values were determined comparing CD57⁺ and CD57⁻ NK cells (n = 23).