GATA3 and IL-13 expression correlate in primary classical Hodgkin lymphoma tissue. Sixteen primary cases of classical Hodgkin lymphoma were analyzed for their correlation of GATA3 and IL-13 after immunohistochemical staining. Samples 1, 5, 6, 8, 9, 11-13, and 15 are of the nodular sclerosis subtype. Samples 2-4, 7, 10, 14, and 16 are of the mixed cellularity subtype. The Pearson product moment correlation resulted in a P value of .0025. The T-distribution hypothesis test resulted in a correlation coefficient of 0.619 (cor = 1 for a perfect linear correlation). In this analysis, 3 cases with only cytoplasmic staining for GATA3 were considered “negative,” because only nuclear GATA3 can bind to the IL-13 promoter.