Figure 1
Low-level positive RQ-PCR samplings in patients in CCR. x-axis, MRD target; y-axis, MRD marker expression level relative to diagnostic level, arbitrarily set to 1. Numbers below the figure depict the number of low-level positive samples, and negative samples in patients with available diagnostic levels. Suggested cutoff levels for RUNX1-RUNX1T1 and NPM1c are shown in red bars and given in numbers. Sensitivity of each test can be understood as the lower of the difference between diagnostic level and the sample quality-dependent sensitivity (typically between 1 × 10−5 and 1 × 10−3) and cutoff level (NPM1c and RUNX1-RUNX1T1).
