Conversion to PCR positivity. x-axis, Time, HR occurred at t = 0. y-axis, Fraction-positive samples in each prerelapse interval. Median number of evaluable MRD profiles in each interval is shown for each molecular marker (panels A-D; range in parentheses). Solid lines, BM; broken lines, PB.A: NPM1c: blue, FLT3-ITD−; red, FLT3-ITD+. B: PML-RARA. C: CBFB-MYH11. D: RUNX1-RUNX1T1.