Comparisons between different molecular markers regarding RDF and t_m. x-axis, Sampling time in months. y-axis, RDF (top), median time from MR to HR (t_m; bottom). Horizontal black lines, top panels: RDF equaling 90%. Bottom panels, t_m equaling 60 days. Blue lines in top panel represent sampling interval necessary to ensure 90% relapse detection. Blue lines in bottom panels show corresponding t_m values. Solid lines, BM; broken lines, PB; NPM1c-based MRD follow-up: black line, FLT3-ITD⁻ and red line, FLT3-ITD⁺. PML-RARA–based MRD follow-up: PB sampling intervals above 6 months not shown as model handles situation of long sampling intervals in very heterogeneous populations poorly.