Figure 4
![Figure 4. Platelet CD40L promotes atherosclerosis initiation. (A) Plaque area of the aortic arch, including the main branch points (brachiocephalic trunk [BCT], left common carotid artery [LCC], left subclavian artery) of Apoe−/− mice, injected every 5 days for 12 weeks with activated Cd40l+/+Apoe−/− or Cd40l−/−Apoe−/− platelets, or vehicle (n = 11/group). (B-D) Representative longitudinal sections (hematoxylin and eosin staining) of the aortic arch and main branch points. Note the early, foam cell-rich atherosclerotic lesions formed in the brachiocephalic trunk. Scale bar represents 200 μm. (E) Plaque area in the aortic root of the same mice (n = 9/group). *P < .05.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/116/20/10.1182_blood-2010-01-261206/7/zh89991060620004.jpeg?Expires=1735526889&Signature=qgUlboB0x2DQczJgNXHmwvHJSQzGr9z4LC8maiMXpgVJWVUPatMTXZDtpDx8B19LDOQK4lueKPeQKmiIX21Tl6LjAX5qT7ch1oTu9s-5ULTte4ErvUdb5k3wNrN0oRNBozzEoO09GDEzBvGa8q7-~uWlngBotOMHgv0M6lwcjbDGm-lz6qPZlWd9qBdo7SodK70psowODSv2cPJwHRKPNpQ4oMTD92w7LKeX8QouBKCHZmSS29yp0D51YG2t7M7PWstustkRkp112RguKRoEmp9QYTj9zWSFsm3E7Wkz~p6CqIASTJK0JBeSpEuYMJBnsCnYcMlPvs8~HAe45baQRg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Platelet CD40L promotes atherosclerosis initiation. (A) Plaque area of the aortic arch, including the main branch points (brachiocephalic trunk [BCT], left common carotid artery [LCC], left subclavian artery) of Apoe−/− mice, injected every 5 days for 12 weeks with activated Cd40l+/+Apoe−/− or Cd40l−/−Apoe−/− platelets, or vehicle (n = 11/group). (B-D) Representative longitudinal sections (hematoxylin and eosin staining) of the aortic arch and main branch points. Note the early, foam cell-rich atherosclerotic lesions formed in the brachiocephalic trunk. Scale bar represents 200 μm. (E) Plaque area in the aortic root of the same mice (n = 9/group). *P < .05.
