Activation status of CD8⁺ T cells during reconstitution in HIV⁺ non-IRIS and HIV⁺ IRIS patients before and during ART. The percentage of central memory (CD45RO⁺CD27⁺; A), HLA-DR⁺ (B), and CD57⁻GrB⁺ (C) cells within CD8⁺ T lymphocytes and Ki67⁺ (E) cells within central memory CD8⁺ T lymphocytes in HIV⁺ non-IRIS (open symbols) and HIV⁺ IRIS patients (filled symbols) were measured before and after ART initiation. The shaded area represents the IQR of IRIS episodes. Dotted lines represent median of the given measurement in healthy donors.