Heatmap of the cytokine data for individual cases. C&Ckine expression for each of the 11 “bimodal” C&Ckines (y-axis) is shown for all cases (x-axis) with the cases sorted into 8 signatures (color boxes along left side x-axis). For display purposes, columns have been standardized to mean of zero and SD = 1. Bimodal cytokines were clustered using Ward linkage and Spearman rank correlation to define distance.