Overexpressing Egfl7 results in partial embryonic lethality and hemorrhaging. (A) The expected and observed number of embryos and pups obtained from Tie2-Egfl7 hemizygous intercrosses at E9.5, E10.5, E12.5, and P5. *P = .004. (B) Gross phenotype of wild-type (i-ii) and Tie2-Egfl7 transgenic embryos (iii-iv) at E10.5 and E12.5. Arrows indicate hemorrhaging in Tie2-Egfl7 mice at E12.5 (iv). Original magnification ×20 (E10.5), ×12 (E12.5). Images were captured on Discovery V20 Stereomicroscope (Carl Zeiss).