IL-23 driven apoptosis and BCL-2 modulation in pediatric B-ALL cells. (A) Left panel: flow cytometric analysis of BCL-2 expression in 5 B-ALL samples transfected or not with anti-miR15a or irrelevant (irr) anti-miR cultured 48 hours with or without IL-23. Left panel: whisker lines represent highest and lowest values, horizontal lines represent median values. Histograms on the right: BCL-2 intracellular staining of one representative experiment is shown. (B) Left panel: analysis of apoptotic cells in 3 B-ALL samples transfected or not with anti-miR15a or irrelevant anti-miR cultured 48 hours with or without IL-23. Left panel: whisker lines represent highest and lowest values, horizontal lines represent median values. Dot plots on the right: annexin V/PI double staining in 1 representative experiment.