Self-reported quality of life during 36 months. (A) Global parameters. (B) Specific health parameters. Data are mean values and 95% confidence intervals. QL indicates global quality of life; RF, role function; PF, physical function; SF, social function; EF, emotional function; CF, cognitive function; DI, diarrhea; CO, constipation; AP, appetite loss; NV, nausea/vomiting; DY, dyspnea; SL, sleep loss; PA, pain; FA, fatigue; and FI, financial problems.