Overall survival and time to transformation. (A) Overall survival for all 44 patients. (B) Overall survival for patients with transformation by histologic (red; n = 19) and clinical (dark red; n = 8) criteria compared with survival for patients without transformation during the observation time (blue; n = 17; P = .02). (C) Time to transformation for all 44 patients. Patients without signs of transformation (including those who died without transformation) are censored.