Time distribution of sequential biopsies and representation of the CNA index. The length of the horizontal lines represents the observation time (years) from diagnosis for each patient. Open-ended lines indicate that the patient was alive at the last follow-up, whereas closed lines indicate the time of death. The 17 upper cases marked with blue did not transform. The 27 lower cases marked with red transformed (clinical transformation criteria were applied for cases no. 12, 13, 15, 19, 23, 24, 26, and 27; the rest transformed to diffuse large B-cell lymphoma [DLBCL]). Blue circles represent samples of FL grade 1/FL2, orange FL grade 3a, and red DLBCL. For the transformation cases without aCGH data from a transformed biopsy the red lines mark the transformation time point. The circle sizes correlate to the CNA index for each sample which is a marker for genomic complexity. Of note, in many cases (patient nos. 3, 5, 6, 15, 21, 22, 29, 31, 35, 38, 40, 41, and 43) the CNA index is lower in biopsies taken later in the disease course.