Immune complex deposition and mesangial cell proliferation in WASp-deficient mice. (A) Representative PAS-stained glomeruli from WASp-deficient and 129 SvEv control mice and immunofluorescence images of IgA, IgG, IgM, and C3 deposition in glomeruli from the same animals. (B) Quantitation of immunofluorescence results from mice of the indicated genotype more than 6 months old measured as in panel B. (C) Circulating immune complexes in mice of the indicated genotypes and ages. (D) Urinary albumin/creatinine ratios in a cohort of WASp-deficient and 129 age-matched control mice.