cAMP formation in G_i2α(+/G184S) platelets. (A) Effect of ADP on cAMP levels after stimulation with forskolin (left) or PGI₂ (right). (B) Percent inhibition of cAMP levels with increasing dosages of ADP after stimulation with forskolin (left) and PGI₂ (right). Mean ± SEM. The data shown represent averaged measurements from 4 (forskolin) or 3 (PGI₂) experiments. One mouse of each genotype was used in each experiment.