MiR-144 reduces ARE-driven gene expression and cellular GSH levels. (A) MiR-144, but not miR-320, repressed reporter activity of an antioxidant response element (ARE) luciferase construct in K562 cells. (B) MiR-144 overexpression decreased gene expression of indicated ARE-driven genes and (C) led to significant reduction in cellular GSH after H₂O₂-induced oxidative stress. This GSH reduction is partially rescued by exogenous NRF2 expression. *Significantly different by Student t test: *P ≤ .05, **P ≤ .001, ***P ≤ .0001.