Fibrin accumulation caused by loss of uPA-uPAR interaction. (A) Representative low-magnification images of liver sections from Plau^+/+ (top left), Plau^GFDhu/GFDhu (top right), Plaur^−/− (bottom left), and Plau^−/− (bottom right) mice stained with fibrin-specific antibodies showing fibrin deposits. Size bars, 100 μm. (B) Enumeration of fibrin foci in the livers of Plau^+/+ (left), Plau^GFDhu/GFDhu (second left), Plaur^−/− (second right), and Plau^−/− (right) mice. Symbols represent individual mice. Horizontal bars show average values. P values were determined by the Student t test, 2-tailed.