ILY₁₄₀FI-induced death in ThCD59^RBC mice associated with a significantly lower RRRVSP compared with ILY₁₄₀SI or ILY₇₀FI. (A-D) Representative tracings show the dynamic changes in RVSP in the WT (A) and ThCD59^RBC mice with ILY₁₄₀FI (B), and the ThCD59^RBC mice with ILY₁₄₀SI (C) and ILY₇₀FI (D). (E) RRRVSP comparison among these mice. RRRVSP (mm Hg/s) = increased systolic pulmonary arterial pressure (in mm Hg)/time (in seconds; black line in panel B). RRRVSP t test. *P < .05 vs ThCD59^RBC mice with ILY₁₄₀FI. Results represent mean ± SEM.