Systemic blood pressures and echocardiogram in ILY-treated mice. (A) Hemolysis in the ThCD59^RBC induced by ILY injection with 3 different dosing schedules induced an immediate, rapid decrease in MABP. Five minutes later, the mice treated with either ILY₁₄₀SI or ILY₇₀FI had a gradual increase in the MABP, but all mice treated with ILY₁₄₀FI died (and had no measurable MABP). *P < .05 (n = 4) compared with the respective baseline level of MABP. (B) Representative echocardiographic frames in the parasternal long-axis view show the dynamic changes in right ventricular volume in the ThCD59^RBC mice treated with different ILY dosing schedules (the full echocardiogram videos are showed in supplemental Videos 1-4). *P < .01 vs WT with ILY₁₄₀FI. (C) Increased percentage of maximal right ventricular area at end-diastole vs baseline right ventricular area in the mice treated with the ILY. *P < .05 vs ILY₁₄₀FI. (D) Elapsed time until maximal right ventricular dilation was achieved in the mice treated with ILY₁₄₀FI and ILY₁₄₀SI. *P < .05 vs ILY₁₄₀FI. Results represent mean ± SEM.