T-cell proliferation after Ab-mediated CD4⁺ and CD8⁺ lymphocyte depletion in nonhuman primates. PB- and LN-derived mononuclear cells were obtained from healthy SIV-uninfected SMs and RMs. (A) Levels of circulating CD4⁺ (left graphs) and CD8⁺ (right graphs) T cells of SMs (black line) and RMs (red line) that express the proliferation marker Ki-67 after Ab-mediated CD4⁺ lymphocyte depletion. (B) Levels of memory (ie, CD28⁺CD95⁺) CD4⁺ T cells that express Ki-67 in the PB (left graph) or LN (right graph) of SMs (black line) and RMs (red line) after Ab-mediated CD4⁺ lymphocyte depletion. (C) Levels of circulating CD4⁺ (left graphs) and CD8⁺ (right graphs) T cells of SMs (black line) and RMs (red line) that express Ki-67 after Ab-mediated CD8⁺ lymphocyte depletion. In all the graphs levels of Ki-67⁺ T cells are shown as percentage variation from baseline (mean ± SD), and the dotted lines indicate the timing of anti-CD4 (A-B) or anti-CD8 (C) monoclonal antibody administrations.