Pharmacokinetic profiles of FVII variants with different activation peptides. Mean plasma concentration of FVII antigen as a function of time after intravenous administration of 0.5 to 1 mg/kg FVII, FVII_C, FVII_IX, and FVII_X to mice. Blood was sampled in a sparse schedule as each compound was administered to a total of 6 to 9 mice, and 3 samples were taken from each animal as described in “Pharmacokinetics.”