HLA-G1 influences cytotoxicity against tumor cells. (A-B) Balb/c mice were injected subcutaneously with M8-pDNA or M8-HLA-G1 tumor cells at day 0. A classic 4-hour ⁵¹Cr-release cytotoxic assay was conducted with NK cells purified from spleens (A) or with total splenocytes (B) as effectors, and YAC-1, M8-pcDNA, or M8-HLA-G1 cells as targets. Results are expressed as the mean percentage lysis from duplicates. Standard deviations were below 5%. Data are from 1 representative experiment of 3.