EGF expression decrease thymic lymphoma growth. (A) Survival analysis of 5- to 6-week-old syngeneic C57BL/6 mice injected intrathymically with 5 × 103 per lobe of lymphoma cell transfectants (□) or controls (■). Lymphoma growth is restricted to the thymus after intrathymic injection and does not metastasize to peripheral organ. When clinical signs of thymic lymphoma became evident (runting, swelling of the thorax, and dyspnea), mice were killed, and thymic lymphoma was confirmed and collected at necropsy. (B) Histogram showing the mean survival times (MSTs) of mice after intrathymic injection of lymphoma cell transfectants or controls. Data are representative of 2 independent experiments with several different clones expressing EGF and controls. Bars represent SD; *P ≤ .05.
