Figure 2
All recipient mice transplanted with whole bone marrow cells expressing oncogenic Nras died after a prolonged latency. Lethally irradiated mice were transplanted with 2.5 × 105 control bone marrow cells (n = 7) or bone marrow cells expressing oncogenic Nras (n = 26) along with same number of competitor cells. (A) Dynamic contribution of donor-derived white blood cells (CD45.2+) in peripheral blood of recipient mice at different time points posttransplant. (B) Kaplan-Meier comparative survival analysis of reconstituted mice. Cumulative survival was plotted against days after transplantation.
