Granulocytic/monocytic precursor cells are expanded in c-Kit⁻ [Lin Sca-1 IL7Rα]^−/low compartment in CMML-like mice. Total bone marrow cells were isolated from control and CMML-like mice and simultaneously stained for myeloid progenitors as well as for granulocytic/monocytic precursors. (A) Regions I-V are defined by characteristic staining pattern of cells, including ER-MP12⁺ ER-MP20⁻, ER-MP12⁺ ER-MP20^mid, ER-MP12⁻ ER-MP20^mid, ER-MP12⁻ ER-MP20^hi, and ER-MP12⁺ ER-MP20^hi, respectively. The density plots and percentages of regions I-V cells in c-Kit⁻ [Lin Sca-1 IL7Rα]^−/low compartment (B) are shown from 1 representative control and 1 CMML-like mouse. (C) Sorted cells from region III were subjected to phospho-flow analysis in the ERK and Stat5 pathways as described in Figure 5.